Abstract

Naturally occurring compounds polyphenols are secondary metabolites of plants, comprised several categories, namely, flavonoids, phenolic acids, lignans and stilbenes. The biological aging process is driven by a series of interrelated mechanisms, including oxidative stress, inflammation status, and autophagy function, through diverse signaling pathways. Moreover, the crucial role of gut microbiota in regulating aging and health status was widely demonstrated. In recent years, the potential anti-aging benefits of polyphenols have been gaining increasing scientific interest due to their capability to modulate oxidative damage, inflammation, autophagy, and gut microbiota. This review highlights the influence of polyphenols in preventing aging disorders and augmenting lifespan based on the influence of oxidative stress, inflammation, autophagy, and gut microbiota, and encourages research on novel polyphenol-based strategies and clinical trials to develop a nutrition-oriented holistic anti-aging therapy.

摘要

天然存在的化合物多酚是植物的次生代谢产物，包括几类，即黄酮类、酚酸类、木脂素类和芪类。生物衰老过程是由一系列相互关联的机制驱动的，包括氧化应激、炎症状态和自噬功能，通过不同的信号通路。此外，肠道微生物群在调节衰老和健康状况方面的关键作用得到广泛证实。近年来，由于多酚具有调节氧化损伤、炎症、自噬和肠道微生物群的能力，其潜在的抗衰老作用越来越受到科学界的关注。本综述基于氧化应激、炎症、自噬、