Considering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice in our country. We conducted a multicenter retrospective study in two different teaching hospitals in Romania, analyzing urine samples from 7719 patients to determine the frequency of incriminating pathogens and their resistance to different antibiotics, in a comparative approach. We determined Escherichia coli (35.98%) to be the most common pathogen with the highest sensitivity to amikacin (S = 91.72%), meropenem (S = 97.17%) and fosfomycin (S = 86.60%) and important resistance to amoxicillin-clavulanic ac. (R = 28.03%) and levofloxacin (R = 37.69%), followed by Klebsiella spp. (22.98%) with the highest sensitivity to amikacin (S = 78.04%) and meropenem (S = 81.35%) and important resistance to amoxicillin-clavulanic ac. (R = 65.58%) and levofloxacin (R = 45.36%); the most frequent Gram-positive pathogen was Enterococcus spp. (19.73%) with the highest sensitivity for vancomycin (S = 93.75%) and fosfomycin (S = 87.5%) and considerable resistance to penicillin (R = 33.52%) and levofloxacin (R = 42.04%). The findings are an important tool in managing UTIs and should be acknowledged as reference research not only for clinicians from Romania but for all physicians treating male UTIs.

中文翻译：

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罗马尼亚男性人群中尿致病菌抗菌谱的临床观察。

考虑到尿路感染（UTIs），这是一个近期的可忽略不计的重大公共卫生问题，尤其是在东欧男性人群上，因此，我们的目标是确定我国泌尿科实践中最常用的抗生素对尿路致病菌的抗药性。我们在罗马尼亚的两家不同的教学医院进行了一项多中心回顾性研究，以比较的方法分析了7719名患者的尿液样本，以确定病原体的发病频率及其对不同抗生素的耐药性。我们确定了大肠杆菌（35.98％）是对丁胺卡那霉素（S = 91.72％），美罗培南（S = 97.17％）和磷霉素（S = 86.60％）敏感性最高的最常见病原体，并对阿莫西林-克拉维酸ac有重要耐药性。（R = 28.03％）和左氧氟沙星（R = 37.69％），其次是克雷伯菌。（22.98％）对阿米卡星（S = 78.04％）和美罗培南（S = 81.35％）的敏感性最高，并且对阿莫西林-克拉维酸ac有重要耐药性。（R = 65.58％）和左氧氟沙星（R = 45.36％）; 革兰氏阳性菌最常见的是肠球菌spp。（19.73％）对万古霉素（S = 93.75％）和磷霉素（S = 87.5％）的敏感性最高，对青霉素（R = 33.52％）和左氧氟沙星（R = 42.04％）的耐药性较高。这些发现是管理UTI的重要工具，不仅对于罗马尼亚的临床医生，而且对于所有治疗男性UTI的医生都应作为参考研究。