Background: The aim of this study was to estimate the frequency of functional gastrointestinal disorders (FGIDs) in infants aged up to 12 months according to the new ROME IV criteria defining these disorders, and to describe the management of FGIDs in France. Methods: This French non-interventional, cross-sectional, and multicenter study was conducted among private-outpatient physicians who each included four consecutive patients aged up to 12 months. The frequency of FGIDs was described using the ROME IV criteria versus clinicians’ diagnosis. The characteristics of infants with and without FGID were compared, and the management of the FGIDs was described. Results: In the 1722 infants analyzed, the following frequencies were observed according to the ROME IV criteria versus the physicians’ diagnosis: regurgitation 41% versus 45%; colic 18% versus 30%; constipation 9% versus 19%; diarrhea 3% versus 8%. Of note, FGID infants were less frequently exclusively breastfeeding at the maternity hospital (p < 0.001), were introduced to cow’s milk earlier after leaving the maternity hospital (p < 0.001), and more frequently had symptoms suggestive of cow’s milk protein allergy (p < 0.001). Physicians frequently recommended an adapted infant formula (in 77% to 82% of cases depending on the FGID diagnosed) and prescribed a specific treatment in 51% to 66% of infants (probiotics: 35% to 64%). Conclusions: This real-world study confirms the high frequency of FGIDs in infants in France, and provides new information regarding the characteristics of FGID infants.

中文翻译：

---

长达12个月的门诊患者的功能性胃肠道疾病：一项法国非干预性研究。

背景：本研究的目的是根据定义这些疾病的新ROME IV标准，评估12月龄以下婴儿的功能性胃肠道疾病（FGID）的发生率，并描述法国的FGID管理。方法：这项法国非介入，横断面和多中心研究是在私人门诊医师中进行的，每位医师均包括连续四个年龄不超过12个月的患者。FGID的发生率使用ROME IV标准与临床医生的诊断进行了描述。比较了有和没有FGID的婴儿的特征，并描述了FGID的管理。结果：在分析的1722例婴儿中，根据ROME IV标准与医生的诊断相比，观察到以下频率：返流41％对45％；反流41％对45％。绞痛18％对30％；便秘9％对19％；腹泻3％比8％。值得注意的是，FGID婴儿在妇产医院的纯母乳喂养频率较低（p <0.001），在离开妇产科医院后更早被引入了牛奶中（p <0.001），并且更经常出现暗示对牛奶蛋白过敏的症状（p <0.001）。医师经常推荐一种适合的婴儿配方食品（在77％至82％的病例中取决于所诊断的FGID），并在51％至66％的婴儿中规定了特殊的治疗方法（益生菌：35％至64％）。结论：这项现实世界的研究证实了法国婴儿中FGID的频率很高，并提供了有关FGID婴儿特征的新信息。