The association of gestational hypertension (GH) with future hypertension in Japanese women is unclear. Hence, this study aimed to examine the association between GH and the risk of future hypertension in middle-aged-to-older Japanese women. A case-control study was performed, including 62 hypertensive women (case) and 75 nonhypertensive women (control). GH during the first pregnancy was diagnosed on the basis of the Maternal and Child Health Handbook record. Hypertensive women were recruited from outpatients in the hospital and residents who completed an annual health check-up in a community. Hypertension was defined as blood pressure with systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or taking antihypertensive medications. The average age (SD) of the cases and controls at the time of recruitment was 63.1 (8.4) and 57.7 (9.4), respectively. The multivariable-adjusted odds ratio of GH for hypertension in middle-aged-to-older women was 4.2 (95% confidence interval, 1.0–17.5) after adjustment for potential confounding factors such as age and body-mass index (BMI) upon recruitment, prepregnancy BMI, and age at first delivery. In conclusion, GH can be an independent risk factor for future hypertension among Japanese women.

中文翻译：

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妊娠高血压是中老年妇女高血压的危险因素。

在日本女性中，妊娠高血压与未来高血压的关系尚不清楚。因此，本研究旨在检验日本中老年女性中GH与未来高血压风险之间的关系。进行了一项病例对照研究，包括62名高血压妇女（病例）和75名非高血压妇女（对照）。根据《母婴健康手册》记录，首次妊娠期间的GH被诊断出来。从医院的门诊病人和居民中招募了高血压妇女，这些妇女在社区中完成了年度健康检查。高血压的定义是收缩压≥140mmHg和/或舒张压≥90mmHg或服用降压药。招募时病例和对照的平均年龄（SD）为63.1（8。4）和57.7（9.4）。在对潜在的混杂因素（例如年龄和身体质量指数（BMI））进行调整后，中老年妇女的GH的多变量调整后的优势比为4.2（95％置信区间，1.0-17.5） ，怀孕前的BMI和首次分娩的年龄。总之，GH可能是日本女性未来高血压的独立危险因素。