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Front cover story: Eur. J. Immunol. 6'20
European Journal of Immunology ( IF 5.4 ) Pub Date : 2020-06-05 , DOI: 10.1002/eji.202070060


Our colorful cover features represent the infiltration of M1 phenotype macrophages in cardiac tissue with EAM acquired by immunofluorescence. M1 phenotype macrophages can be discriminated by anti‐F4/80, anti‐CD86 and DAPI. The image is taken from Lu et al. (pp. 795–808), where the authors show that fibroblast transdifferentiation induced selective apoptosis of M1 macrophages through TNF/TNFR1, and the conversion of surviving CCR2+ macrophages into CX3CR1+ M2 and their settlement in the heart, which are dependent on the leptin‐PI3K or leptin‐Akt pathway. The image is obtained from one of two independent experiments and the color of the image has been digitally altered for the cover.
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中文翻译:

封面故事:Eur。J.免疫。6'20

我们丰富多彩的封面特征代表通过免疫荧光获得的EAM在心脏组织中浸润M1表型巨噬细胞。M1表型巨噬细胞可以通过抗F4 / 80,抗CD86和DAPI进行区分。该图像取自Lu等人。(pp。795–808),作者证明成纤维细胞转分化通过TNF / TNFR1诱导M1巨噬细胞选择性凋亡,并将存活的CCR2 +巨噬细胞转化为CX3CR1 + M2并在心脏中沉降,这依赖于瘦素PI3K或瘦素Akt途径。该图像是从两个独立实验之一获得的,并且图像的颜色已针对封面进行了数字更改。
图片
更新日期:2020-06-05
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