IgE‐mediated food allergy remains a significant and growing worldwide problem. Sublingual immunotherapy (SLIT) shows an excellent safety profile for food allergy, but the clinical efficacy needs to be improved. This study assessed the effects of the Toll‐like receptor 4 agonist outer membrane protein (Omp) 16 from Brucella abortus combined with cow´s milk proteins (CMP) through the sublingual route to modulate cow's milk allergy in an experimental model.

中文翻译：

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舌下 Omp16 驱动的食物过敏临床前模型中过敏性肠道反应的重定向

IgE 介导的食物过敏仍然是一个重要且日益严重的全球性问题。舌下免疫疗法（SLIT）对食物过敏显示出极好的安全性，但临床疗效有待提高。本研究评估了流产布鲁氏菌的 Toll 样受体 4 激动剂外膜蛋白 (Omp) 16 与牛奶蛋白 (CMP) 结合通过舌下途径在实验模型中调节牛奶过敏的效果。