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Equus caballus papillomavirus type 2 (EcPV2) in co-occurring vulvar and gastric lesions of a pony.
Research in Veterinary Science ( IF 2.4 ) Pub Date : 2020-06-05 , DOI: 10.1016/j.rvsc.2020.06.003
Ilaria Porcellato 1 , Paola Modesto 2 , Katia Cappelli 1 , Katia Varello 2 , Simone Peletto 2 , Chiara Brachelente 1 , Isabella Martini 2 , Luca Mechelli 1 , Angelo Ferrari 2 , Alessandro Ghelardi 3 , Elisabetta Razzuoli 2
Affiliation  

In horses, squamous cell carcinomas (SCCs) are the most common malignant tumors developing on non-pigmented skin, muco-cutaneous areas, like external genitalia, and, less frequently, in the stomach. Growing evidence suggests Equus caballus papillomavirus type 2 (EcPV2) as causative agent of genital SCCs. Our case report describes a 20-year-old, female, mixed-breed pony with co-occurring vulvar papilloma and in situ carcinoma and gastric SCC. Both lesions were positive for the same EcPV2, as confirmed by DNA sequencing. E6 mRNA expression was observed both in vulvar lesions and gastric SCC, while L1 mRNA was expressed in the vulvar tumor. To the best of the Authors' knowledge, this is the first report of an association between EcPV2 and equine gastric squamous cell carcinoma, with co-occurring EcPV2-positive genital lesions. Further studies are required to assess the real prevalence and the possible role of this viral type in these equine tumors.



中文翻译:

小马同时出现外阴和胃部病变的马属马球状乳头瘤病毒2型(EcPV2)。

在马匹中,鳞状细胞癌(SCC)是最常见的恶性肿瘤,会在无色素的皮肤,粘膜皮肤区域(如外生殖器)上发生,并且在胃部发生的频率更低。越来越多的证据表明,马属caballus乳头瘤病毒类型2(EcPV2)如生殖器SCC的病原体。我们的病例报告描述了共同发生外阴乳头状瘤和20岁,女性,混种小马原位癌和胃癌。DNA测序证实,两个病变对于相同的EcPV2均为阳性。在外阴部病变和胃鳞癌中均观察到E6 mRNA表达,而L1 mRNA在外阴部肿瘤中表达。就作者所知,这是EcPV2与马胃鳞状细胞癌之间同时发生EcPV2阳性生殖器病变的首次报道。需要进一步的研究来评估这种病毒类型在这些马肿瘤中的实际患病率和可能的作用。

更新日期:2020-06-23
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