Purpose

To analyze the therapeutic benefits of limbal-supported contact lens (CL) wear in patients with ocular sequelae due to Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN).

Methods

This interventional study enrolled 10 chronic SJS/TEN eyes with a spectacle best-corrected visual acuity (BCVA) of between 0.01 and 0.7 that were fitted with a limbal-supported CL. At baseline and at after 3-months CL use, CL-wear BCVA and the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) scores were measured, and then compared. Incidence rates and severities of adverse events were also analyzed.

Results

At after 3-months CL use, BCVA with the fitted CL significantly improved compared to that with spectacle correction at baseline (LogMAR: 0.76−0.15) (P = 0.0039), all NEI VFQ-25 scores improved, however, only in ocular pain and mental health showed statistically significant improvement (P = 0.0078 and 0.0039). No serious adverse events were observed during the follow-up.

Conclusion

Wearing of the limbal-supported CL improved vision compared to spectacles and reduced ocular pain in patients with ocular sequelae due to SJS/TEN.

中文翻译：

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临床试验评估角膜缘支撑的隐形眼镜佩戴对史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症引起的眼部后遗症的治疗效果。

目的

分析角膜缘支撑式隐形眼镜 (CL) 佩戴对史蒂文斯-约翰逊综合征 (SJS)/中毒性表皮坏死松解症 (TEN) 眼后遗症患者的治疗益处。

方法

这项介入性研究招募了 10 只慢性 SJ​​S/10 只眼睛，其最佳矫正视力 (BCVA) 介于 0.01 和 0.7 之间，并装有角膜缘支撑的 CL。在基线和 CL 使用 3 个月后，测量 CL 佩戴 BCVA 和 25 项国家眼科研究所视觉功能问卷 (NEI VFQ-25) 分数，然后进行比较。还分析了不良事件的发生率和严重程度。

结果

在使用 3 个月 CL 后，与基线时眼镜矫正相比，佩戴 CL 的 BCVA 显着改善（LogMAR：0.76-0.15）（P = 0.0039），所有 NEI VFQ-25 评分均有所改善，但仅在眼痛方面有所改善和心理健康显示出统计学上的显着改善（P = 0.0078 和 0.0039）。随访期间未观察到严重不良事件。

结论

与眼镜相比，佩戴角膜缘支撑的 CL 可改善视力，并减轻因 SJS/TEN 引起的眼部后遗症患者的眼痛。