Regulation of hematopoietic stem and progenitor cells (HSPCs) self-renewal, expansion, and differentiation is an inevitable process for normal hematopoiesis in the bone marrow (BM) niche, where leukemia cells are born, proliferate and occupy the microenvironment. External mediators such as extracellular vesicles (EVs) shed from leukemia cells, are one of the most important cell to cell communicators, and leading to phenotype and genotype modification and subsequently, fate of the cell. This review highlights recent evidences about the possible roles of leukemia derived-EVs on maintenance, proliferation, and death of HSPCs in a same microenvironment as leukemia cells. In addition, it focuses on mechanisms involved in the transformation of BM niche in favor of leukemia microenvironment remodeling by leukemia derived-EVs.

造血干细胞和祖细胞 (HSPCs) 自我更新、扩增和分化的调节是骨髓 (BM) 生态位中正常造血的必然过程，白血病细胞在这里出生、增殖并占据微环境。白血病细胞脱落的细胞外囊泡 (EV) 等外部介质是最重要的细胞与细胞通讯器之一，可导致表型和基因型修饰，进而导致细胞的命运。这篇综述强调了关于白血病衍生的 EV 在与白血病细胞相同的微环境中对 HSPC 的维持、增殖和死亡的可能作用的最新证据。此外，它侧重于参与 BM 生态位转化的机制，以促进白血病衍生的 EV 对白血病微环境的重塑。