Efficiently mapping sensory stimuli onto motor programs is crucial for rapidly choosing appropriate behavioral responses. While neuronal mechanisms underlying simple, one-to-one sensorimotor mapping have been extensively studied, how the brain achieves complex, many-to-one sensorimotor mapping remains unclear. Here, we recorded single neuron activity from the lateral intraparietal (LIP) cortex of monkeys trained to map multiple spatial positions of visual cue onto two opposite saccades. We found that LIP neurons’ activity was consistent with directly mapping multiple cue positions to the associated saccadic direction (SDir) regardless of whether the visual cue appeared in or outside neurons’ receptive fields. Unlike the explicit encoding of the visual categories, such cue–target mapping (CTM)–related activity covaried with the associated SDirs. Furthermore, the CTM was preferentially mediated by visual neurons identified by memory-guided saccade. These results indicate that LIP plays a crucial role in the early stage of many-to-one sensorimotor transformation.

中文翻译：

---

外侧顶内皮层中多对一感觉运动映射的神经元相关性。

有效地将感觉刺激映射到运动程序上对于快速选择适当的行为反应至关重要。虽然已经广泛研究了简单的一对一感觉运动映射的神经元机制，但大脑如何实现复杂的多对一感觉运动映射仍不清楚。在这里，我们记录了猴子的外侧顶内 (LIP) 皮层的单个神经元活动，这些活动经过训练将视觉线索的多个空间位置映射到两个相对的眼跳上。我们发现 LIP 神经元的活动与将多个提示位置直接映射到相关的扫视方向 (SDir) 是一致的，无论视觉提示出现在神经元的感受野中还是外部。与视觉类别的显式编码不同，这种线索-目标映射 (CTM) 相关活动与相关的 SDirs 共变。此外，CTM 优先由记忆引导的扫视识别的视觉神经元介导。这些结果表明 LIP 在多对一感觉运动转换的早期阶段起着至关重要的作用。