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Anti-Inflammatory and Gut Microbiota Modulatory Effect of Lactobacillus rhamnosus Strain LDTM 7511 in a Dextran Sulfate Sodium-Induced Colitis Murine Model.
Microorganisms ( IF 4.5 ) Pub Date : 2020-06-04 , DOI: 10.3390/microorganisms8060845
Soyoung Yeo 1 , Hyunjoon Park 2 , Eunsol Seo 1 , Jihee Kim 1, 3 , Byoung Kook Kim 3 , In Suk Choi 3 , Chul Sung Huh 2, 4
Affiliation  

Inflammatory bowel disease (IBD) is a group of conditions involving chronic relapsing-remitting inflammation of the gastrointestinal tract with an unknown etiology. Although the cause–effect relationship between gut microbiota and IBD has not been clearly established, emerging evidence from experimental models supports the idea that gut microbes play a fundamental role in the pathogenesis of IBD. As microbiome-based therapeutics for IBD, the beneficial effects of probiotics have been found in animal colitis models and IBD patients. In this study, based on the dextran sulfate sodium (DSS)-induced colitis mouse model, we investigated Lactobacillus rhamnosus strain LDTM 7511 originating from Korean infant feces as a putative probiotic strain for IBD. The strain LDTM 7511 not only alleviated the release of inflammatory mediators, but also induced the transition of gut microbiota from dysbiotic conditions, exhibiting the opposite pattern in the abundance of DSS colitis-associated bacterial taxa to the DSS group. Our findings suggest that the strain LDTM 7511 has the potential to be used as a probiotic treatment for IBD patients in comparison to L. rhamnosus GG (ATCC 53103), which has been frequently used for IBD studies.

中文翻译:

鼠李糖乳杆菌菌株LDTM 7511在葡聚糖硫酸钠诱导的结肠炎小鼠模型中的抗炎和肠道菌群调节作用。

炎性肠病(IBD)是一组病因不明的涉及慢性复发性胃肠道炎症的疾病。尽管尚未明确建立肠道菌群与IBD之间的因果关系,但实验模型的新兴证据支持了肠道微生物在IBD发病机理中起重要作用的观点。作为基于微生物组的IBD治疗剂,益生菌的有益作用已在动物结肠炎模型和IBD患者中发现。在这项研究中,基于硫酸葡聚糖钠(DSS)诱导的结肠炎小鼠模型,我们调查了源自韩国婴儿粪便的鼠李糖乳杆菌菌株LDTM 7511,作为IBD的推定益生菌菌株。LDTM 7511菌株不仅减轻了炎症介质的释放,而且还诱导了肠道菌群从营养不良状态转变,在DSS结肠炎相关细菌类群的数量上与DSS组呈现出相反的模式。我们的发现表明,与经常用于IBD研究的鼠李糖乳杆菌GG(ATCC 53103)相比,菌株LDTM 7511有潜力用作IBD患者的益生菌治疗。
更新日期:2020-06-04
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