The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently known as COVID-19. Therefore, genomic sequencing and therapeutic clinical trials are being conducted to develop effective antiviral agents. Several reports have investigated FDA-approved drugs as well as in silico virtual screening approaches such as molecular docking and modeling to find novel antiviral agents. Until now, antiparasitic drugs such as chloroquine have shown the most relevant results. Furthermore, there is an urgent need to understand the pathogenesis of this novel coronavirus, its transmission routes, surface survival and evolution in the environment. So far, the scientific community has indicated a possible transmission of COVID-19 via blood transfusion which is challenging in the case of asymptomatic individuals. Protocols for pathogen inactivation are also needed. In this paper, we reviewed recent findings about this life-threatening pandemic.

中文翻译：

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从武汉到 COVID-19 大流行：对其发病机制、潜在治疗方法和最新进展的最新回顾。

引起严重传染性呼吸道感染的新型人类冠状病毒（SARS-CoV-2）的出现对全世界的公共卫生构成严重威胁。迄今为止，尚无针对这种疾病（目前称为 COVID-19）的特异性抗病毒药物。因此，正在进行基因组测序和治疗临床试验以开发有效的抗病毒药物。几份报告研究了 FDA 批准的药物以及计算机虚拟筛选方法，例如分子对接和建模，以寻找新型抗病毒药物。到目前为止，氯喹等抗寄生虫药物已显示出最相关的结果。此外，迫切需要了解这种新型冠状病毒的发病机制、传播途径、表面生存和在环境中的进化。到目前为止，科学界已经表明 COVID-19 可能通过输血传播，这对于无症状个体来说是一个挑战。还需要病原体灭活方案。在本文中，我们回顾了有关这种危及生命的流行病的最新发现。