Origanum compactum Benth., is a Moroccan medicinal plant known by its local name as Zaatar. In Morocco, it has various traditional applications such as the use to treat diabetes, metabolic disorders, digestive, and respiratory problems. In this review, we critically highlighted current investigations on the ethnopharmacological studies, the phytochemistry, pharmacological investigations, biotechnological applications, and future perspective of O. compactum. A bibliometric electronic search in worldwide accepted scientific databases such as ScienceDirect, PubMed, SpringerLink, Web of Science, Scopus, Wiley Online, and Google Scholar was carried out to gather on O. compactum. Chemical analysis using GC‐MS and/or HPLC allowed the identification of several bioactive compounds such as terpenoids and phenolic acids. Furthermore, O. compactum extracts and essential oils have been tested for various biological activities such as antibacterial, antioxidant, antiparasitic, antifungal, and anticancer effects. Moreover, an alignment between traditional use and biological effects was demonstrated, in particular for the antimicrobial activity. These properties are related to O. compactum bioactive components, especially the volatile compounds such as thymol and carvacrol. The pharmacological mechanisms involve several cellular and molecular targeted actions. Moreover, the biological potential of this species had led some laboratories to apply the biotechnological tools for its regeneration.

中文翻译：

---

从传统用途到生物技术应用的紧凑牛至。

Origanum compactum Benth。，是一种摩洛哥药用植物，其本地名称为Zaatar。在摩洛哥，它具有多种传统应用，例如用于治疗糖尿病，代谢紊乱，消化系统和呼吸系统疾病。在这篇评论中，我们严格地强调了有关民族药理学研究，植物化学，药理学研究，生物技术应用和紧凑型石。的未来展望的当前研究。在全球公认的科学数据库（如ScienceDirect，PubMed，SpringerLink，Web of Science，Scopus，Wiley Online和Google Scholar）中进行了文献计量电子搜索，以收集O. compactum。。使用GC-MS和/或HPLC进行化学分析可以鉴定出几种生物活性化合物，例如萜类化合物和酚酸。此外，已经测试了密实麦草提取物和精油的各种生物活性，例如抗菌，抗氧化剂，抗寄生虫，抗真菌和抗癌作用。此外，还证明了传统用途与生物学效果之间的一致性，特别是在抗菌活性方面。这些性质与紧凑型O.生物活性成分，尤其是挥发性化合物，如百里香酚和香芹酚。药理机制涉及几种细胞和分子靶向作用。此外，该物种的生物潜力已导致一些实验室将生物技术工具应用于其再生。