A new synthetic strategy for the construction of two polypropionate subunits of discodermolide, a highly potent anticancer natural product, is reported. The strategy relies on two key reactions: a Shimizu non‐aldol reaction, a stereoselective hydrogenolysis of alkenyl epoxides, to generate the syn hydroxy‐methyl moiety and a NaBH₄‐BF₃.OEt₂ mediated hydride addition reaction. By utilizing this strategy, two different fragments of discodermolide, C9‐C13 subunit and C15‐C21 subunit have been successfully synthesized.

中文翻译：

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Discodermolide C9-C13和C15-C21亚基的合成

报道了一种新的合成策略，用于构建discodermolide的两个聚丙酸酯亚基，这是一种高效的抗癌天然产物。的策略依赖于两个关键反应：一个清水非醛醇缩合反应，烯基环氧化物的立体选择性氢解，以生成顺式羟基-甲基部分和加入NaBH ₄ -BF ₃ .OEt ₂介导的氢化加成反应。通过使用该策略，成功合成了二个编码异构体的不同片段，C9-C13亚基和C15-C21亚基。