Immunoadjuvants are added to the vaccines in order to enhance and prolong the antigen specific immune responses when used in consolidation with specific vaccine antigens. This permits the use of antigen in lower quantity and allows immunization protocols practicing the vaccine with smaller doses. Self-healing hydrogels have the ability to heal the damages instinctively and reinstate its framework to ordinariness in absence of external stimuli. Moreover, self-healing hydrogel having various properties such as shear-thinning and reversible sol-gel transformation properties allow it to be readily delivered via injection. Therefore, in the present review, self- healing hydrogel is projected to be used as a carrier for sustained release of peptide and as an analogous to immunoadjuvant. The sustained release property of self-healing hydrogel may be credited to the changes in the structure in response to internal or external stimuli. In addition to the huge potential of stimuli-responsive self-healing hydrogels, they also exhibit good mechanical properties. These properties make self-healing hydrogel as a smart material in delivering the vaccines. Moreover, we have also summarized diverse range of physical and chemical reactions reported for the scale-up of self-healing hydrogels in this review.

当与特定疫苗抗原结合使用时，将免疫佐剂添加到疫苗中以增强和延长抗原特异性免疫反应。这允许使用较少量的抗原，并允许以较小剂量实施疫苗的免疫方案。自愈水凝胶能够在没有外部刺激的情况下本能地修复损伤，并恢复其框架结构。此外，具有各种特性（如剪切稀化和可逆的溶胶-凝胶转变特性）的自修复水凝胶可通过注射轻松将其输送。因此，在本综述中，预计自愈合水凝胶将用作持续释放肽的载体并类似于免疫佐剂。自修复水凝胶的持续释放特性可以归因于响应内部或外部刺激的结构变化。除了具有刺激响应的自我修复水凝胶的巨大潜力外，它们还具有良好的机械性能。这些特性使自修复水凝胶成为运送疫苗的明智材料。此外，在这篇综述中，我们还总结了自愈水凝胶按比例放大所报道的各种物理和化学反应。