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Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis.
Cancer Letters ( IF 9.7 ) Pub Date : 2020-06-03 , DOI: 10.1016/j.canlet.2020.05.014
Dhiego Chaves de Almeida Bastos 1 , Jeffrey Weinberg 1 , Vinodh A Kumar 2 , David T Fuentes 3 , Jason Stafford 3 , Jing Li 4 , Ganesh Rao 1 , Sujit S Prabhu 1
Affiliation  

Stereotactic Radiosurgery has become the main treatment for patients with limited number of brain metastases (BM). Recently, with the increasing use of this modality, there is a growth in recurrence cases. Recurrence after radiation therapy can be divided in changes favoring either tumor recurrence or radiation necrosis (RN). Laser Interstitial Thermal Therapy (LITT) is minimally invasive treatment modality that has been used to treat primary and metastatic brain tumors. When associated with real-time thermometry using Magnetic Resonance Imaging, the extent of ablation can be controlled to provide maximum coverage and avoid eloquent areas. The objective of this study was to investigate the use of LITT in the treatment of BM. An extensive review of the relevant literature was conducted and the outcome results are discussed. There is an emphasis on safety and local control rate of patients treated with this modality. The findings of our study suggest that LITT is a viable safe technique to treat recurrent BM, especially in patients with deep-seated lesions where surgical resection is not an option.



中文翻译:

激光间质热疗法治疗脑转移和放射坏死。

立体定向放射外科手术已成为脑转移瘤(BM)数量有限的患者的主要治疗方法。近来,随着这种方式的越来越多的使用,复发病例有所增加。放射治疗后的复发可以分为有利于肿瘤复发或放射坏死(RN)的改变。激光间质热疗法(LITT)是一种微创治疗方式,已用于治疗原发性和转移性脑肿瘤。当与使用磁共振成像的实时测温相关联时,可以控制消融的程度,以提供最大的覆盖范围并避免雄辩的区域。这项研究的目的是研究LITT在治疗BM中的应用。对相关文献进行了广泛的回顾,并讨论了结果。强调使用这种方式治疗的患者的安全性和局部控制率。我们的研究结果表明,LITT是治疗复发性BM的可行安全技术,尤其是对于深部病变的患者,这些患者无法进行手术切除。

更新日期:2020-06-03
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