Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one (1) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one (2) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The two compounds showed weak anti-TMV activity with inhibition rates of 28.9 and 32.6%. These rates are close to that of positive control.

中文翻译：

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两种新的异喹啉类生物碱及其抗TMV活性

两种新的异喹啉生物碱，3-羟基-1-(7-羟基-6-甲基异喹啉-1-基)丙-1-一 (1) 和 3-羟基-1-(7-甲氧基-6-甲基异喹啉-1- yl)propan-1-one (2) 是从 Thalictrumglunosissimum 的全株中分离出来的。它们的结构是通过 HR-ESI-MS 和广泛的 1D 和 2D NMR 光谱研究确定的。测试了化合物 1 和 2 的抗烟草花叶病毒（抗 TMV）活性。两种化合物均表现出较弱的抗 TMV 活性，抑制率为 28.9% 和 32.6%。这些比率接近阳性对照的比率。