Abstract

From the Vietnamese plant Macrosolen tricolor (Lecomte) Danser, one new diarylpropanoid, named macrotricolorin A (1) together with three diarylheptanoids including bisdemethoxycurcumin (2), demethoxycurcumin (3) and curcumin (4), were isolated. Their structures were elucidated by intensive analyses of their IR, UV, HR-ESI-MS and NMR (1 D & 2 D) spectra. It is the first time that diarylalkanoids have been reported from the genus Macrosolen. Compound 1 exhibited anti-inflammatory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 with an IC₅₀ value of 27.54 ± 1.75 μM.

摘要

从越南植物Macrosolen tricolor (Lecomte) Danser 中分离出一种新的二芳基丙烷，命名为 macrotricolorin A ( 1 ) 以及三种二芳基庚烷，包括双去甲氧基姜黄素 ( 2 )、去甲氧基姜黄素 ( 3 ) 和姜黄素 ( 4 )。通过对其 IR、UV、HR-ESI-MS 和 NMR（1 维和 2 维）光谱的深入分析，阐明了它们的结构。这是第一次从Macrosolen属中报道二芳基链烷烃。化合物1对脂多糖 (LPS) 诱导的 RAW264.7 中的一氧化氮 (NO) 产生具有抗炎活性，IC ₅₀值为 27.54 ± 1.75 μM。