Within recent decades, the development of nanotechnology has made a significant contribution to the progress of various fields of study, including the domains of medical and pharmaceutical sciences. A substantially transformed arena within the context of the latter is the development and production of various injectable parenteral formulations. Indeed, recent decades have witnessed a rapid growth of the marketed and pipeline nanotechnology-based injectable products, which is a testimony to the remarkability of the aforementioned contribution. Adjunct to the ability of nanomaterials to deliver the incorporated payloads to many different targets of interest, nanotechnology has substantially assisted to the development of many further facets of the art. Such contributions include the enhancement of the drug solubility, development of long-acting locally and systemically injectable formulations, tuning the onset of the drug’s release through the endowment of sensitivity to various internal or external stimuli, as well as adjuvancy and immune activation, which is a desirable component for injectable vaccines and immunotherapeutic formulations. The current work seeks to provide a comprehensive review of all the abovementioned contributions, along with the most recent advances made within each domain. Furthermore, recent developments within the domains of passive and active targeting will be briefly debated.

中文翻译：

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纳米技术作为可注射肠胃外制剂开发的平台：对专有技术和最新技术的全面回顾。

在最近的几十年中，纳米技术的发展为包括医学和药学领域在内的各个研究领域的进步做出了重大贡献。在后者的背景下，一个基本上转变的舞台是各种注射用肠胃外制剂的开发和生产。的确，最近几十年来，市场上销售的基于管线的基于纳米技术的可注射产品迅速增长，这证明了上述贡献的卓越性。除了纳米材料将掺入的有效载荷传递到许多不同的目标方面的能力外，纳米技术还极大地帮助了本领域许多其他方面的发展。这些贡献包括提高药物溶解度，开发长效局部和全身可注射制剂，通过赋予对各种内部或外部刺激的敏感性以及辅助和免疫激活来调节药物释放的发作，这是可注射疫苗和免疫治疗制剂的理想成分。当前的工作旨在对上述所有贡献以及每个领域的最新进展进行全面的回顾。此外，将简要讨论被动和主动目标领域内的最新发展。它是可注射疫苗和免疫治疗制剂的理想成分。当前的工作旨在对上述所有贡献以及每个领域内的最新进展进行全面的回顾。此外，将简要讨论被动和主动目标领域内的最新发展。它是可注射疫苗和免疫治疗制剂的理想成分。当前的工作旨在对上述所有贡献以及每个领域内的最新进展进行全面的回顾。此外，将简要讨论被动和主动目标领域内的最新发展。