Randomized controlled studies have shown that antioxidative supplements are effective in suppressing the progression of age-related macular degeneration and visual display terminal syndrome. However, effects of their general use in the real-world and by young and healthy individuals have not been well documented. We analyzed 27 participants who were under 35 years of age and had no diagnosed diseases. Mean functional visual acuity (FVA) score and visual maintenance ratio, which represent quick recognition of a target, both measured using FVA system, were better (both p < 0.01) in subjects who had had regular antioxidative supplement intake for more than 2 months (11 participants) compared with those who had not. Systemic data, i.e., total cholesterol, hemoglobin A1c (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) levels, which correspond to chronic low-grade inflammation, were lower (all p < 0.05) in the former. Overall, hs-CRP levels had a correlation with total cholesterol (p < 0.05) and a trend of correlation with HbA1c (p = 0.054) levels. Thus, current real-world data showed that young, healthy participants who had a regular intake of antioxidative supplements had better visual acuity and systemic levels of metabolic and low-grade inflammation markers. This study will help promote future research into the effects of general antioxidative supplement use.

中文翻译：

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在年轻人和健康成年人中使用抗氧化补充剂的眼部和全身影响：实际的跨部门数据。

随机对照研究表明，抗氧化补充剂可有效抑制与年龄有关的黄斑变性和视觉显示终末综合征的发展。但是，尚未充分记录它们在现实世界中以及年轻健康人的普遍使用所产生的影响。我们分析了35岁以下且未诊断出疾病的27位参与者。均能通过FVA系统测量的平均功能性视力（FVA）评分和视觉维持率更好（两者均p与未服用抗氧化补充剂的时间超过2个月的受试者（11名参与者）相比，<0.01）。前者的全身性数据，即总胆固醇，血红蛋白A1c（HbA1c）和高敏感性C反应蛋白（hs-CRP）水平较低，与慢性低度炎症反应相对应（均p <0.05）。总体而言，hs-CRP水平与总胆固醇相关（p <0.05），并且与HbA1c相关（p= 0.054）的水平。因此，当前的现实世界数据显示，定期摄入抗氧化补充剂的年轻健康参与者具有更好的视敏度以及全身性代谢和低度炎症标志物水平。这项研究将有助于促进对一般抗氧化补充剂使用效果的未来研究。