Microneedle patches based on dissolving, detachable microneedle technology (Russian patent No. 2652567; US patent EFS No. 32735812; WO/2019/231360) are novel dermatological products that allow safe, painless and effective reduction of epidermal wrinkles after six procedures. The purpose of this study was two‐fold (a) to assess the safety and efficacy of microneedle patches comprising 650 microneedles containing hyaluronic and ferulic acids after 6 procedures of applying the applicator to the skin for 25 min; and (b) to correlate our previously reported ex vivo findings.

中文翻译：

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基于溶解、可拆卸微针技术的微针贴片，可改善眶周区域的皮肤质量。第 2 部分：临床评估。

基于溶解、可拆卸微针技术的微针贴片（俄罗斯专利号 2652567；美国专利 EFS 号 32735812；WO/2019/231360）是一种新型皮肤病产品，可在六次手术后安全、无痛且有效地减少表皮皱纹。本研究的目的是双重的（a）在将涂抹器应用于皮肤 25 分钟的 6 道程序后，评估由 650 根含有透明质酸和阿魏酸的微针组成的微针贴片的安全性和有效性；(b) 关联我们之前报道的离体研究结果。