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Disruption of the GABAergic system contributes to the development of perioperative neurocognitive disorders after anesthesia and surgery in aged mice.
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2020-06-02 , DOI: 10.1111/cns.13388 Wen Zhang 1 , Bing-Rui Xiong 2 , Long-Qing Zhang 1 , Xian Huang 3 , Wen-Chang Zhou 1 , Qian Zou 4 , Anne Manyande 5 , Jie Wang 6 , Xue-Bi Tian 1 , Yu-Ke Tian 1
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2020-06-02 , DOI: 10.1111/cns.13388 Wen Zhang 1 , Bing-Rui Xiong 2 , Long-Qing Zhang 1 , Xian Huang 3 , Wen-Chang Zhou 1 , Qian Zou 4 , Anne Manyande 5 , Jie Wang 6 , Xue-Bi Tian 1 , Yu-Ke Tian 1
Affiliation
Perioperative neurocognitive disorders (PND) are associated with cognitive impairment in the preoperative or postoperative period, and neuroinflammation is thought to be the most important mechanisms especially during the postoperative period. The GABAergic system is easily disrupted by neuroinflammation. This study investigated the impact of the GABAergic system on PND after anesthesia and surgery.
中文翻译：
GABA 能系统的破坏有助于老年小鼠麻醉和手术后围手术期神经认知障碍的发展。
围手术期神经认知障碍（PND）与术前或术后的认知障碍有关，神经炎症被认为是最重要的机制，尤其是在术后期间。GABAergic 系统很容易被神经炎症破坏。本研究调查了 GABA 能系统对麻醉和手术后 PND 的影响。
更新日期：2020-08-10
中文翻译：
GABA 能系统的破坏有助于老年小鼠麻醉和手术后围手术期神经认知障碍的发展。
围手术期神经认知障碍（PND）与术前或术后的认知障碍有关，神经炎症被认为是最重要的机制，尤其是在术后期间。GABAergic 系统很容易被神经炎症破坏。本研究调查了 GABA 能系统对麻醉和手术后 PND 的影响。
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