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Altered resting-state functional connectivity and effective connectivity of the habenula in irritable bowel syndrome: A cross-sectional and machine learning study.
Human Brain Mapping ( IF 4.8 ) Pub Date : 2020-06-03 , DOI: 10.1002/hbm.25038 Cui P Mao 1 , Fen R Chen 2 , Jiao H Huo 3 , Liang Zhang 3 , Gui R Zhang 1 , Bing Zhang 1 , Xiao Q Zhou 1
Human Brain Mapping ( IF 4.8 ) Pub Date : 2020-06-03 , DOI: 10.1002/hbm.25038 Cui P Mao 1 , Fen R Chen 2 , Jiao H Huo 3 , Liang Zhang 3 , Gui R Zhang 1 , Bing Zhang 1 , Xiao Q Zhou 1
Affiliation
Irritable bowel syndrome (IBS) is a disorder involving dysfunctional brain–gut interactions characterized by chronic recurrent abdominal pain, altered bowel habits, and negative emotion. Previous studies have linked the habenula to the pathophysiology of negative emotion and pain. However, no studies to date have investigated habenular function in IBS patients. In this study, we investigated the resting‐state functional connectivity (rsFC) and effective connectivity of the habenula in 34 subjects with IBS and 34 healthy controls and assessed the feasibility of differentiating IBS patients from healthy controls using a machine learning method. Our results showed significantly enhanced rsFC of the habenula‐left dorsolateral prefrontal cortex (dlPFC) and habenula‐periaqueductal grey (PAG, dorsomedial part), as well as decreased rsFC of the habenula‐right thalamus (dorsolateral part), in the IBS patients compared with the healthy controls. Habenula‐thalamus rsFC was positively correlated with pain intensity (r = .467, p = .005). Dynamic causal modeling (DCM) revealed significantly decreased effective connectivity from the right habenula to the right thalamus in the IBS patients compared to the healthy controls that was negatively correlated with disease duration (r = −.407, p = .017). In addition, IBS was classified with an accuracy of 71.5% based on the rsFC of the habenula‐dlPFC, habenula‐thalamus, and habenula‐PAG in a support vector machine (SVM), which was further validated in an independent cohort of subjects (N = 44, accuracy = 65.2%, p = .026). Taken together, these findings establish altered habenular rsFC and effective connectivity in IBS, which extends our mechanistic understanding of the habenula's role in IBS.
中文翻译:
肠易激综合征中缰核的静息状态功能连通性和有效连通性的改变:横断面和机器学习研究。
肠易激综合征 (IBS) 是一种涉及脑-肠相互作用功能障碍的疾病,其特征是慢性复发性腹痛、排便习惯改变和负面情绪。以前的研究将缰绳与负面情绪和疼痛的病理生理联系起来。然而,迄今为止,还没有研究调查 IBS 患者的缰功能。在这项研究中,我们调查了 34 名 IBS 受试者和 34 名健康对照者的静息状态功能连接 (rsFC) 和缰核的有效连接性,并评估了使用机器学习方法区分 IBS 患者与健康对照的可行性。我们的结果显示缰骨-左背外侧前额叶皮层(dlPFC)和缰骨-导水管周围灰质(PAG,背内侧部分)的 rsFC 显着增强,与健康对照组相比,IBS 患者的缰骨-右丘脑(背外侧部分)的 rsFC 降低。Habenula-thalamus rsFC 与疼痛强度呈正相关(r = .467,p = .005)。动态因果模型 (DCM) 显示,与与疾病持续时间呈负相关的健康对照相比,IBS 患者从右缰骨到右丘脑的有效连接显着降低(r = -.407,p = .017)。此外,基于支持向量机 (SVM) 中缰核-dlPFC、缰核-丘脑和缰核-PAG 的 rsFC,IBS 的分类准确率为 71.5%,这在独立的受试者队列中得到了进一步验证。N = 44,准确率 = 65.2%,p= .026)。总之,这些发现在 IBS 中建立了改变的缰核 rsFC 和有效连接,这扩展了我们对缰核在 IBS 中作用的机制理解。
更新日期:2020-08-10
中文翻译:
肠易激综合征中缰核的静息状态功能连通性和有效连通性的改变:横断面和机器学习研究。
肠易激综合征 (IBS) 是一种涉及脑-肠相互作用功能障碍的疾病,其特征是慢性复发性腹痛、排便习惯改变和负面情绪。以前的研究将缰绳与负面情绪和疼痛的病理生理联系起来。然而,迄今为止,还没有研究调查 IBS 患者的缰功能。在这项研究中,我们调查了 34 名 IBS 受试者和 34 名健康对照者的静息状态功能连接 (rsFC) 和缰核的有效连接性,并评估了使用机器学习方法区分 IBS 患者与健康对照的可行性。我们的结果显示缰骨-左背外侧前额叶皮层(dlPFC)和缰骨-导水管周围灰质(PAG,背内侧部分)的 rsFC 显着增强,与健康对照组相比,IBS 患者的缰骨-右丘脑(背外侧部分)的 rsFC 降低。Habenula-thalamus rsFC 与疼痛强度呈正相关(r = .467,p = .005)。动态因果模型 (DCM) 显示,与与疾病持续时间呈负相关的健康对照相比,IBS 患者从右缰骨到右丘脑的有效连接显着降低(r = -.407,p = .017)。此外,基于支持向量机 (SVM) 中缰核-dlPFC、缰核-丘脑和缰核-PAG 的 rsFC,IBS 的分类准确率为 71.5%,这在独立的受试者队列中得到了进一步验证。N = 44,准确率 = 65.2%,p= .026)。总之,这些发现在 IBS 中建立了改变的缰核 rsFC 和有效连接,这扩展了我们对缰核在 IBS 中作用的机制理解。