The remodel the structure of chromatin (RSC) nucleosome remodeling complex is a conserved chromatin regulator with roles in chromatin organization, especially over nucleosome depleted regions therefore functioning in gene expression. Recent reports in Saccharomyces cerevisiae have identified specificities in RSC activity toward certain types of nucleosomes. RSC has now been shown to preferentially evict nucleosomes containing the histone variant H2A.Z in vitro. Furthermore, biochemical activities of distinct RSC complexes has been found to differ when their nucleosome substrate is partially unraveled. Mammalian BAF complexes, the homologs of yeast RSC and SWI/SNF complexes, are also linked to nucleosomes with H2A.Z, but this relationship may be complex and extent of conservation remains to be determined. The interplay of remodelers with specific nucleosome substrates and regulation of remodeler outcomes by nucleosome composition are tantalizing questions given the wave of structural data emerging for RSC and other SWI/SNF family remodelers.

中文翻译：

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专业 RSC：保守染色质重塑剂的底物特异性。

染色质结构重塑 (RSC) 核小体重塑复合物是一种保守的染色质调节因子，在染色质组织中发挥作用，特别是在核小体耗尽区域，因此在基因表达中发挥作用。最近关于酿酒酵母的报告已经确定了 RSC 活性对某些类型核小体的特异性。目前，RSC 已被证明可以在体外优先驱逐含有组蛋白变体 H2A.Z 的核小体。此外，当核小体底物部分解开时，不同 RSC 复合物的生化活性也有所不同。哺乳动物 BAF 复合物是酵母 RSC 和 SWI/SNF 复合物的同源物，也与具有 H2A.Z 的核小体相关，但这种关系可能很复杂，并且保守程度仍有待确定。鉴于 RSC 和其他 SWI/SNF 家族重塑剂的结构数据不断出现，重塑剂与特定核小体底物的相互作用以及核小体组成对重塑剂结果的调节是诱人的问题。