The survival of allogeneic fetuses during pregnancy is a rather paradoxical phenomenon with a complex mechanism. Chemokine ligand12 (CXCL12) and its receptors CXC chemokine receptor (CXCR)4 and 7 are extensively found in placenta tissues and cells, including trophoblast cells, vascular endothelial cells, and decidual stromal and decidual immune cells (eg, NK cells and regulatory T cells). Evidence has illustrated that the CXClL12/CXCR4/CXCR7 axis could enhance the cross talk at the maternal‐fetal interface through multiple processes, such as invasion and placental angiogenesis, which appears to be critical signaling components in placentation and fetal outcome. In addition, an increasing number of studies have demonstrated that the CXCL12/CXCR4/CXCR7 axis also stands out for its pleiotropic roles in several pregnancy‐associated diseases (eg, recurrent spontaneous abortion (RSA), pre‐eclampsia (PE), and preterm labor). In the present review, the different biological properties and signaling in physiological and pathological pregnancy conditions of CXCL12/CXCR4/CXCR7 axis were discussed, with the aim of obtaining a further understanding of the regulatory mechanisms and highlighting their potential as a target for therapeutic approaches.

中文翻译：

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CXCL12 在正常妊娠和病理妊娠中的作用：综述。

同种异体胎儿在怀孕期间的存活是一个相当矛盾的现象，其机制复杂。趋化因子配体 12 (CXCL12) 及其受体 CXC 趋化因子受体 (CXCR)4 和 7 广泛存在于胎盘组织和细胞中，包括滋养层细胞、血管内皮细胞、蜕膜基质和蜕膜免疫细胞（例如，NK 细胞和调节性 T 细胞） ）。有证据表明，CXClL12/CXCR4/CXCR7 轴可以通过多种过程增强母胎界面的串扰，例如侵入和胎盘血管生成，这似乎是胎盘形成和胎儿结局的关键信号成分。此外，越来越多的研究表明，CXCL12/CXCR4/CXCR7 轴在多种妊娠相关疾病（例如，复发性自然流产 (RSA)、先兆子痫 (PE) 和早产)。在本综述中，讨论了 CXCL12/CXCR4/CXCR7 轴在生理和病理妊娠条件下的不同生物学特性和信号传导，目的是进一步了解调节机制并突出其作为治疗方法靶点的潜力。