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New Insights on Acute and Chronic Schistosomiasis: Do We Need a Redefinition?
Trends in Parasitology ( IF 9.6 ) Pub Date : 2020-06-03 , DOI: 10.1016/j.pt.2020.05.009
Federico Gobbi 1 , Francesca Tamarozzi 1 , Dora Buonfrate 1 , Lisette van Lieshout 2 , Zeno Bisoffi 3 , Emmanuel Bottieau 4 ,
Affiliation  

A precise timeframe to differentiate acute schistosomiasis (AS) and chronic schistosomiasis (CS) is not well defined. Based on recent published literature, lung nodular lesions in AS and CS seem to have the same pathophysiology, that is, eggs laid in situ by adult worms, during an ectopic migration. Moreover, the occurrence of lung nodules due to clusters of eggs and the systemic immunoallergic reaction of AS (Katayama syndrome) may be two separate clinical entities, which may overlap during the early phase of infection. Consequently, the classical distinction between AS and CS loses much of its conceptual validity. If adult worms play a more important role in the early phase of the disease the clinical management of AS should probably be revised.



中文翻译:

急性和慢性血吸虫病的新见解:我们需要重新定义吗?

区分急性血吸虫病(AS)和慢性血吸虫病(CS)的精确时间框架尚不明确。根据最近发表的文献,肺结节性病变AS和CS似乎有相同的病理生理机制,也就是产卵在原地异位迁移过程中成虫。此外,由于卵簇而引起的肺结节的发生和AS的全身免疫过敏反应(片山综合症)可能是两个独立的临床实体,在感染的早期可能重叠。因此,AS和CS之间的经典区别在很大程度上失去了其概念上的有效性。如果成虫在疾病的早期阶段起着更重要的作用,则可能应修订AS的临床管理。

更新日期:2020-07-15
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