Detection of NaCl by the gustatory system is fundamental for salt intake and tissue homeostasis. Yet, signal transduction mechanisms for salty taste have remained obscure. In this issue of Neuron, Nomura et al. (2020) report that the epithelial sodium channel ENaC, which serves as the salty receptor, is co-expressed with the voltage-activated ATP release channel CALHM1/3 in a subset of taste cells and that these cells mediate amiloride-sensitive salty taste.

中文翻译：

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咸味：从传导到递质释放，稳住钙。

味觉系统检测氯化钠对于盐摄入和组织稳态至关重要。然而，咸味的信号转导机制仍然不清楚。在本期《神经元》中，野村等人。(2020) 报告称，作为咸味受体的上皮钠通道 ENaC 在味觉细胞的子集中与电压激活的 ATP 释放通道 CALHM1/3 共表达，并且这些细胞介导阿米洛利敏感的咸味。