Abstract There is a continuous search for better and more complete in vitro models with mechanical properties closer to in vivo conditions. In this work a manufacturing process, based on a lost core casting technique, is herein reported to produce aneurysm biomodels to perform experimental hemodynamic studies. By using real artery images combined with a lost core casting technique, three materials were tested: paraffin, beeswax and glycerin-based soap. All in vitro biomodels were compared according to their transparency and final structure. Additionally, comparisons between experimental and numerical flow studies were also performed. The results have shown that the biomodels produced with beeswax and glycerine-based soap were the most suitable in vitro models to perform direct flow visualizations of particulate blood analogue fluids. The biomodels proposed in this works, have the potential to provide further insights into the complex blood flow phenomena happening at different kinds of pathologies and answer to important hemodynamics questions that otherwise cannot be tackled with the existing in vitro models.

中文翻译：

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用于血流可视化的颅内动脉瘤生物模型的 3D 制造：低成本制造工艺

摘要 不断寻找更好、更完整的体外模型，其机械性能更接近体内条件。在这项工作中，本文报道了一种基于消失芯铸造技术的制造过程，用于生产动脉瘤生物模型，以进行实验性血液动力学研究。通过使用真实的动脉图像结合失芯铸造技术，测试了三种材料：石蜡、蜂蜡和甘油皂。所有体外生物模型根据其透明度和最终结构进行比较。此外，还进行了实验和数值流动研究之间的比较。结果表明，用蜂蜡和甘油基肥皂制作的生物模型是最适合进行颗粒血液类似物流体直接流动可视化的体外模型。