The recent advances in skin-interfaced wearable sensors have enabled tremendous potential toward personalized medicine and digital health. Compared with traditional healthcare, wearable sensors could perform continuous and non-invasive data collection from the human body and provide an insight into both fitness monitoring and medical diagnostics. In this review, we summarize the latest progress of skin-interfaced wearable sensors along with their integrated systems. We first introduce the strategies of materials selection and structure design that can be accommodated for intimate contact with human skin. Current development of physical and biochemical sensors is then classified and discussed with an emphasis on their sensing mechanisms. System-level integration including power supply, wireless communication, and data analysis are also briefly discussed. We conclude with an outlook of this field and identify the key challenges and opportunities for future wearable devices and systems.

皮肤接口可穿戴式传感器的最新进展为个性化医疗和数字健康提供了巨大潜力。与传统的医疗保健相比，可穿戴式传感器可以从人体执行连续且非侵入性的数据收集，并提供对健身监测和医学诊断的深刻见解。在这篇综述中，我们总结了皮肤接口可穿戴传感器及其集成系统的最新进展。我们首先介绍可以适应与人体皮肤紧密接触的材料选择和结构设计策略。然后对物理和生化传感器的最新发展进行分类和讨论，重点是其传感机制。系统级集成，包括电源，无线通信，还简要讨论了数据分析。我们以对这一领域的展望作为总结，并确定了未来可穿戴设备和系统的主要挑战和机遇。