Poly (γ-glutamic acid) (γ-PGA) has been found widespread applications in biomedical field because of its excellent water solubility, biocompatibility, and bioactivity. Herein, a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate (ELA). The functionalized γ-PGA compound (γ-PGA-ELA) ethanol solution can facilely produce colorless and transparent coatings on various inorganic, metal, and polymeric substrates, especially for the lumen of slender catheters (length up to 2 m, and inner diameter down to 1 mm). The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo. In addition, the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion, and the as-prepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy. More importantly, the functionalized γ-PGA coating exhibit good hemocompatibility, low cytotoxicity, and satisfactory histocompatibility. The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections.

聚（γ-谷氨酸）（γ-PGA）因其优异的水溶性，生物相容性和生物活性而在生物医学领域得到了广泛的应用。在此，通过一锅法将γ-PGA与阳离子月桂酰精氨酸乙酯（ELA）静电组装，容易地制备了水不溶性γ-PGA抗菌化合物。功能化的γ-PGA化合物（γ-PGA-ELA）乙醇溶液可在各种无机，金属和聚合物基材上轻松生产无色透明涂层，特别是用于细长导管的内腔（长度可达2 m，内径减小）至1毫米）。功能化的γ-PGA涂层在体外和体内均表现出卓越的抗菌功效。另外，通过熔融挤出将γ-PGA化合物用作聚烯烃的抗菌添加剂，并且所制备的抗菌聚烯烃显示出有利的抗菌功效。更重要的是，功能化的γ-PGA涂层具有良好的血液相容性，低细胞毒性和令人满意的组织相容性。拟议的γ-PGA化合物具有巨大的潜力，可以作为安全，多功能的候选抗菌药物来对抗生物医学设备相关的感染。