This work models the behavior of a liquid-particle suspension on the surface of a tablet during the pharmaceutical film-coating process. The model uses the “mixture modeling” approach and the lubrication approximation method to simulate how the suspension moves and dries on the surface of a tablet, considering how important physical properties of the suspension, such as the density and viscosity, change when the carrier fluid evaporates. The model also accounts for the absorption of the coating suspension inside the core of the porous tablet, yielding the tablet water content, a key quantity characterizing the coating process. The numerical results, obtained with the gPROMS Modelbuilder platform, agree with experimental data taken from the literature and Volume-Of-Fluid CFD simulations.

这项工作模拟了药物薄膜包衣过程中片剂表面上液体颗粒悬浮液的行为。该模型使用“混合物建模”方法和润滑近似方法来模拟悬浮液如何在片剂表面上移动和干燥，同时考虑到悬浮液在载液中的重要物理特性（例如密度和粘度）如何变化蒸发。该模型还考虑了多孔片剂核心内部包衣悬浮液的吸收，产生了片剂的水含量，这是表征包衣过程的关键量。用gPROMS Modelbuilder平台获得的数值结果与从文献和流体CFD体积模拟获得的实验数据一致。