It is generally accepted that mitochondrial Ca²⁺ controls the pace of mitochondrial bioenergetics and thus ATP production. Szibor et al. challenge this paradigm, proposing that the balance between ATP consumption and production depends on mitochondrial pyruvate supply via the malate-aspartate shuttle (MAS) and is controlled by cytosolic Ca²⁺.

中文翻译：

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Cytosolic Ca2+ 负责监督线粒体市场丙酮酸的 MAS 生产。

人们普遍认为，线粒体 Ca ²⁺控制线粒体生物能学的速度，从而控制 ATP 的产生。西博尔等人。挑战这种范式，提出 ATP 消耗和生产之间的平衡取决于通过苹果酸-天冬氨酸穿梭 (MAS)供应的线粒体丙酮酸，并受细胞溶质 Ca ²⁺控制。