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Catalytic synthesis of thiazolidines by the reaction of Nef-isocyanide reaction
Research on Chemical Intermediates ( IF 3.3 ) Pub Date : 2020-04-27 , DOI: 10.1007/s11164-020-04163-2
Amneh Daghlavi , Elaheh Kowsari , Majid Abdouss , Mohammad Hadi Ghasemi , Elham Asadi

A practical and efficient method for the synthesis of thiazolidine derivatives via Nef-isocyanide three-component reaction using supported phosphoric acid on graphene oxide (GO-H2PO4) is described. In this study, a relatively simple method starting with cyclic and acyclic thiourea was employed. The catalyst was characterized using FTIR, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction techniques. Using a combination of acetonitrile as solvent and GO-H2PO4 as a catalytic system, the best results were obtained. All products were characterized using melting point, FTIR, MASS, 1H NMR, and 13C NMR techniques. The use of commercially available chemicals, reusability of the catalyst, high yields, decreased environmental hazards, with no need for the separation of stereoisomers, and, consequently, a reduced number of overall steps are the advantages of this approach that make it an appropriate choice at an increased scale.



中文翻译:

Nef-异氰化物反应催化合成噻唑烷

描述了一种实用且有效的方法,该方法通过在氧化石墨烯(GO-H 2 PO 4)上使用负载的磷酸通过Nef-异氰化物三组分反应合成噻唑烷衍生物。在这项研究中,采用了一种相对简单的方法,从环状和无环硫脲开始。使用FTIR,扫描电子显微镜,能量分散X射线光谱和X射线衍射技术对催化剂进行了表征。使用乙腈作为溶剂,GO-H 2 PO 4作为催化体系,可获得最佳结果。所有产品均使用熔点,FTIR,MASS,1 H NMR和13进行表征13 C NMR技术。使用可商购的化学品,催化剂,高收率,可重用性环境危害降低,而无需立体异构体的分离,并且因此,总体步骤的数量减少是使得它的适当选择这种方法的优点规模扩大。

更新日期:2020-04-27
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