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Powering DNA strand-displacement reactions with a continuous flow reactor
Natural Computing ( IF 2.1 ) Pub Date : 2020-06-03 , DOI: 10.1007/s11047-020-09795-2
Xinyu Cui , Dominic Scalise , Rebecca Schulman

Living systems require a sustained supply of energy and nutrients to survive. These nutrients are ingested, transformed into low-energy waste products, and excreted. In contrast, synthetic DNA strand-displacement reactions typically run within closed systems provided with a finite initial supply of reactants. Once the reactants are consumed, all net reactions halt and the system ceases to function. Here we run DNA strand-displacement reactions in a continuous flow reactor, infusing fresh reactants and withdrawing waste, enabling the system to dynamically update its outputs in response to changing inputs. Running DNA strand-displacement reactions inside of continuous flow reactors allows the system to be re-used for multiple rounds of computation, which could enable the execution of more elaborate information processing tasks, including single-rail negation and sequential logic circuits.



中文翻译:

用连续流动反应器为DNA链置换反应提供动力

生命系统需要持续的能量和营养供应才能生存。这些营养物质被摄入,转化为低能耗废物,并被排泄。相反,合成DNA链置换反应通常在封闭的系统中进行,该系统设有有限的初始反应物供应。一旦反应物被消耗掉,所有净反应都将停止,系统停止运行。在这里,我们在连续流动的反应器中进行DNA链置换反应,注入新鲜的反应物并回收废物,使系统能够根据输入的变化动态更新其输出。在连续流动反应器内部运行DNA链置换反应可使该系统重复使用多次计算,从而可以执行更复杂的信息处理任务,

更新日期:2020-06-03
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