The development of pathological or compensatory-and-adaptive reactions in homoeothermic animals during various periods of hypothermia can be caused by shifts in the respiratory functions of the mitochondria. Short-term hypothermia promoted an increase in the rates of the glutamate- and succinate-dependent respiration of mitochondria. Phosphorylation rate increased as well, while oxidative phosphorylation coefficient (P/O), respiratory control, and 2,4-DNP sensitivity depended. Changes in respiratory characteristics in the dynamics of prolonged hypothermia depends on the type of substrate. Prolongation of hypothermia to 1 h was associated with further intensification of succinate-dependent respiration, decrease in P/O and respiratory control, while prolongation of hypothermia to 3 h led to their normalization. The majority of respiratory characteristics of glutamate-dependent respiration did not change under these conditions and their levels were the same as during short-term hypothermia.

中文翻译：

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大鼠肝线粒体的呼吸特征取决于中度低温的持续时间

在体温过低的不同时期，恒温动物的病理或补偿和适应反应的发展可能是由线粒体呼吸功能的变化引起的。短期低温促进了线粒体依赖谷氨酸和琥珀酸的呼吸速率的增加。磷酸化率也增加，而氧化磷酸化系数 (P/O)、呼吸控制和 2,4-DNP 敏感性取决于。长期低温的动态呼吸特征的变化取决于底物的类型。低温延长至 1 小时与琥珀酸盐依赖性呼吸的进一步加强、P/O 和呼吸控制的降低有关，而低温延长至 3 小时导致其正常化。