Vestibular nucleus (VN) and cerebellar flocculus are known as the core candidates for the neuroplasticity of vestibular system. However, it has been still elusive how to induce the artificial neuroplasticity, especially caused by an electrical stimulation, and assess the neuronal information related with the plasticity. To understand the electrically induced neuroplasticity, the neuronal potentials in VN responding to the repeated electrical stimuli were examined. Galvanic vestibular stimulation (GVS) was applied to excite the neurons in VN, and their activities were measured by an extracellular neural recording technique. Thirty-eight neuronal responses (17 for the regular and 21 for irregular neurons) were recorded and examined the potentials before and after stimulation. Two-third of the population (63.2%, 24/38) modified the potentials under the GVS repetition before stimulation (), and more than half of the population (21/38, 55.3%) changed the potentials after stimulation (). On the other hand, the plasticity-related neuronal modulation was hardly observed in the temporal responses of the neurons. The modification of the active glutamate receptors was also investigated to see if the repeated stimulation changed the number of both types of glutamate receptors, and the results showed that AMPA and NMDA receptors decreased after the repeated stimuli by 28.32 and 16.09%, respectively, implying the modification in the neuronal amplitudes.

中文翻译：

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重复的前庭前庭刺激改变了前庭核中的神经元电位。

前庭神经核（VN）和小脑絮状体是前庭系统神经可塑性的核心候选人。然而，如何诱发人工神经可塑性，特别是由电刺激引起的神经可塑性，以及评估与可塑性有关的神经元信息，仍然是难以捉摸的。为了理解电诱导的神经可塑性，检查了VN中对重复的电刺激作出反应的神经元电位。应用前庭电刺激（GVS）刺激VN中的神经元，并通过细胞外神经记录技术测量其活性。记录了38个神经元反应（正常神经元为17个，不规则神经元为21个），并检查了刺激前后的电位。人口的三分之二（63.2％，），超过一半的人口（21 / 38，55.3％）在刺激后改变了电位（）。另一方面，在神经元的时间响应中几乎未观察到可塑性相关的神经元调节。还研究了活性谷氨酸受体的修饰，以观察重复刺激是否改变了两种类型的谷氨酸受体的数量，结果表明，重复刺激后，AMPA和NMDA受体分别降低了28.32％和16.09％，这表明神经元振幅的改变。