Aim. Cirrhosis is rare in systemic lupus erythematosus (SLE) patients with a poor prognosis. This study is aimed at retrospectively analyzing our single-center experience to explore the characteristics of cirrhosis in SLE patients. Methods. SLE patients with cirrhosis from 2012 to 2019 were enrolled. SLE diagnosis was rigorously confirmed by a medical record review according to the revised 1997 American College of Rheumatology classification criteria for SLE. The diagnosis of liver cirrhosis was based on a combination of clinical, laboratory, and imaging criteria features. We conducted a case-control study in SLE patients complicated with the cirrhosis group and the age-, sex-, and entry-time-matched noncirrhosis group. Results. A total of 21 patients with SLE cirrhosis were enrolled, 3 males and 18 females. The median age at the time of cirrhosis diagnosis was years, and the mean disease duration of SLE before cirrhosis was years. The most common initial presentation was the involvement of the hematological system in 9 patients and then skin and mucosal involvement in 5 patients, arthritis in 4 patients, and nephritis in 3 patients. Patients with cirrhosis had a significantly higher rate of hematological system involvement (thrombocytopenia and leukopenia) and worse liver function; a higher level of immune globulin G had higher mortality () than patients without cirrhosis. Conclusions. Cirrhosis is a rare and severe subtype of SLE with a poor prognosis. Those patients with hematological system involvement and impaired liver function should be paid more attention.

中文翻译：

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系统性红斑狼疮伴肝硬化的临床特点。

瞄准。预后不良的系统性红斑狼疮 (SLE) 患者很少发生肝硬化。本研究旨在回顾性分析我们的单中心经验，以探索 SLE 患者肝硬化的特征。方法。纳入 2012 年至 2019 年的 SLE 肝硬化患者。根据 1997 年美国风湿病学会修订的 SLE 分类标准，通过医疗记录审查严格确认了 SLE 诊断。肝硬化的诊断基于临床、实验室和影像学标准特征的组合。我们对合并肝硬化组和年龄、性别和入组时间匹配的非肝硬化组的 SLE 患者进行了病例对照研究。结果. 共纳入SLE肝硬化患者21例，男3例，女18例。肝硬化诊断时的中位年龄为年，肝硬化前 SLE 的平均病程为年。最常见的初始表现是 9 名患者的血液系统受累，然后是 5 名患者的皮肤和黏膜受累，4 名患者的关节炎和 3 名患者的肾炎。肝硬化患者的血液系统受累率（血小板减少和白细胞减少）明显更高，肝功能更差；较高水平的免疫球蛋白 G 死亡率较高（)比没有肝硬化的患者。结论。肝硬化是一种罕见且严重的 SLE 亚型，预后较差。血液系统受累、肝功能受损的患者应引起重视。