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The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids.
Journal of Immunology Research ( IF 4.1 ) Pub Date : 2020-05-20 , DOI: 10.1155/2020/7352637
Drahomira Holmannova 1 , Lenka Borska 2 , Ctirad Andrys 3 , Pavel Borsky 1, 2 , Jan Kremlacek 2 , Kvetoslava Hamakova 4 , Vit Rehacek 5 , Andrea Malkova 1 , Tereza Svadlakova 1, 3 , Vladimir Palicka 6 , Jan Krejsek 3 , Zdenek Fiala 1
Affiliation  

Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.

中文翻译:

牛皮癣和代谢综合征对全身炎症和核酸氧化损伤的影响。

背景。银屑病是一种慢性全身炎症性疾病,与多种合并症相关,包括代谢综合征 (MetS)。血清钙卫蛋白、ANGPTL8 和核酸氧化损伤可能与这两种疾病有关。本研究描述了银屑病和 MetS 对全身炎症标志物(钙卫蛋白和 ANGPTL8)和核酸氧化损伤标志物血清水平的影响。还评估了钙卫蛋白和 ANGPTL8 的血清水平对于监测银屑病活动(诊断标志物)的适用性。方法。临床检查(PASI 评分、MetS)、酶联免疫吸附测定(ELISA)和酶免疫测定(EIA)。血清钙卫蛋白、ANGPTL8、8-羟基-2-脱氧鸟苷、8-羟基鸟苷和8-羟基鸟嘌呤。结果和结论。银屑病显着升高血清钙卫蛋白水平和血清核酸氧化损伤水平,但不升高血清ANGPTL8水平。MetS 的存在并没有显着影响银屑病患者或对照组的钙卫蛋白、ANGPTL8 和核酸氧化损伤的血清水平。看来钙卫蛋白的血清水平(但不是ANGPTL8的血清水平)可以用作监测银屑病活动性的生物标志物。
更新日期:2020-05-20
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