Aims. Talin-1 is a cytoskeletal protein that binds integrin, thereby leading to integrin activation and affecting focal adhesions. Recently, talin-1 expression was reported to be downregulated in human atherosclerotic plaques. However, blood levels of soluble talin-1 (sTalin-1) in patients with atherosclerotic disease, such as coronary artery disease (CAD), have not been elucidated. Methods. We measured plasma sTalin-1 levels in 349 patients undergoing elective coronary angiography. The severity of CAD was represented as the number of stenotic coronary vessels and segments. Results. Of the 349 study patients, CAD was found in 194 patients, of whom 88 had 1-vessel disease (1-VD), 60 had 2-vessel disease (2-VD), and 46 had 3-vessel disease (3-VD). Plasma sTalin-1 levels were higher in 194 patients with CAD than in 155 without CAD (CAD(-) group) (median 0.30 vs. 0.23 ng/mL, ). A stepwise increase in sTalin-1 levels was found depending on the number of >50% stenotic coronary vessels: 0.23 in CAD(-), 0.29 in 1-VD, 0.30 in 2-VD, and 0.32 ng/mL in 3-VD group, respectively, (). High sTalin-1 level (>0.28 ng/mL) was found in 36% of CAD(-), 51% of 1-VD, 53% of 2-VD, and 59% of 3-VD group (). sTalin-1 levels also correlated with the number of >50% stenotic segments (, ). The multivariate analysis revealed that sTalin-1 levels were independently associated with CAD. The odds ratio for CAD was 1.83 () for high sTalin-1 level (>0.28 ng/mL) (). Conclusions. Plasma sTalin-1 levels in patients with CAD were found to be high and to be associated with the presence and severity of CAD, suggesting a role of sTalin-1 in the progression of coronary atherosclerosis.

中文翻译：

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冠状动脉疾病患者可溶性 Talin-1 的高血浆水平。

目标。Talin-1 是一种细胞骨架蛋白，可与整合素结合，从而导致整合素激活并影响粘着斑。最近，据报道 talin-1 表达在人类动脉粥样硬化斑块中下调。然而，尚未阐明患有动脉粥样硬化疾病（如冠状动脉疾病 (CAD)）的患者的可溶性 talin-1 (sTalin-1) 的血液水平。方法。我们测量了 349 名接受选择性冠状动脉造影的患者的血浆 sTalin-1 水平。CAD 的严重程度以狭窄冠状血管和节段的数量表示。结果。在 349 名研究患者中，194 名患者发现 CAD，其中 88 名患有 1 支血管病变（1-VD），60 名患有 2 支血管病变（2-VD），46 名患有 3 支血管病变（3-VD） ）。194 名 CAD 患者的血浆 sTalin-1 水平高于 155 名非 CAD 患者（CAD(-) 组）（中位数 0.30 对 0.23 ng/mL，）。发现 sTalin-1 水平逐步增加取决于 >50% 狭窄冠状血管的数量：CAD(-) 中为 0.23，1-VD 中为 0.29，2-VD 中为 0.30，3-VD 中为 0.32 ng/mL组，分别，（）。在 36% 的 CAD(-)、51% 的 1-VD、53% 的 2-VD 和 59% 的 3-VD 组中发现了高 sTalin-1 水平 (>0.28 ng/mL) (）。sTalin-1 水平也与 >50% 狭窄段的数量相关（, ）。多变量分析显示 sTalin-1 水平与 CAD 独立相关。CAD的优势比为1.83（)对于高 sTalin-1 水平 (>0.28 ng/mL) (）。 结论。发现 CAD 患者的血浆 sTalin-1 水平较高，并且与 CAD 的存在和严重程度相关，提示 sTalin-1 在冠状动脉粥样硬化进展中的作用。