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TopMatch-web: pairwise matching of large assemblies of protein and nucleic acid chains in 3D.
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2020-06-01 , DOI: 10.1093/nar/gkaa366
Markus Wiederstein 1 , Manfred J Sippl 1
Affiliation  

Frequently, the complete functional units of biological molecules are assemblies of protein and nucleic acid chains. Stunning examples are the complex structures of ribosomes. Here, we present TopMatch-web, a computational tool for the study of the three-dimensional structure, function and evolution of such molecules. The unique feature of TopMatch is its ability to match the protein as well as nucleic acid chains of complete molecular assemblies simultaneously. The resulting structural alignments are visualized instantly using the high-performance molecular viewer NGL. We use the mitochondrial ribosomes of human and yeast as an example to demonstrate the capabilities of TopMatch-web. The service responds immediately, enabling the interactive study of many pairwise alignments of large molecular assemblies in a single session. TopMatch-web is freely accessible at https://topmatch.services.came.sbg.ac.at.

中文翻译:

TopMatch-web:3D中蛋白质和核酸链的大型装配的成对匹配。

通常,生物分子的完整功能单元是蛋白质和核酸链的组装体。核糖体的复杂结构是令人震惊的例子。在这里,我们介绍TopMatch-web,这是一种用于研究此类分子的三维结构,功能和演化的计算工具。TopMatch的独特之处在于它能够同时匹配蛋白质和完整分子装配体的核酸链。使用高性能分子查看器NGL可以立即可视化最终的结构排列。我们以人类和酵母的线粒体核糖体为例来说明TopMatch-web的功能。该服务会立即做出响应,从而使您可以在单个会话中交互式研究大型分子装配体的许多成对比对。
更新日期:2020-06-27
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