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Reproducibility of animal research in light of biological variation.
Nature Reviews Neuroscience ( IF 34.7 ) Pub Date : 2020-06-02 , DOI: 10.1038/s41583-020-0313-3
Bernhard Voelkl 1 , Naomi S Altman 2 , Anders Forsman 3 , Wolfgang Forstmeier 4 , Jessica Gurevitch 5 , Ivana Jaric 1 , Natasha A Karp 6 , Martien J Kas 7 , Holger Schielzeth 8 , Tom Van de Casteele 9 , Hanno Würbel 1
Affiliation  

Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental treatments can vary with both genotype and environmental conditions. In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. We also present a road map towards better practices in view of improving the reproducibility of animal research.



中文翻译:

根据生物变异进行动物研究的可重复性。

环境相关的生物变异对实验动物研究中的结果的可重复性提出了独特的挑战,因为生物体对实验治疗的反应会随着基因型和环境条件而变化。2019 年 3 月,动物生物学、实验设计和统计学专家聚集在瑞士布洛奈,讨论应对这一挑战的策略。与目前实验动物研究中严格标准化的黄金标准相比,我们建议通过研究样本和条件的多样化,积极将生物学变异纳入研究设计,从而使用研究样本和条件的系统异质化。在这里,我们提供了这种方法的科学原理,希望研究人员、监管机构、资助者和编辑可以接受这种范式转变。为了提高动物研究的可重复性,我们还提出了实现更好实践的路线图。

更新日期:2020-06-02
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