当前位置: X-MOL 学术Int. J. Radiat. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Proposals of models for new formulations of the current complication-free cure (P+) and uncomplicated tumor control probability (UTCP) concepts, and total normal tissue complication probability of late complications.
International Journal of Radiation Biology ( IF 2.6 ) Pub Date : 2020-03-31 , DOI: 10.1080/09553002.2020.1741722
Terman Frometa-Castillo 1 , Anil Pyakuryal 2 , Amadeo Wals-Zurita 3 , Asghar Mesbahi 4
Affiliation  

This study proposes phenomenological models for total normal tissue complication probability (TNTCP) and NTCP0. NTCP0 is a new acronym for reformulating the current complication-free cure (P+) and uncomplicated tumor control probability (UTCP) concepts, and TNTCP will reformulate the current NTCP involving multiple organs at risks. The current probabilistic concepts are incoherently formulated with mathematical operations of tumor control probability (TCP) and normal tissue complication probability (NTCP) that are associated with different stochastic processes and random variables. NTCP0 is equal to NTCP0 (normal tissue non-complication probability) that is calculated as the ratio of a number of patients of a population without late complications and a total of them. As a cumulative distribution function (CDF) of late complications, TNTCP = sum(NTCPi), where NTCPi is the NTCP of the ith late complication. TNTCP is also a new acronym, and the probabilistic complement of NTCP0, then NTCP0 = 100% − TNTCP. The NTCP0/TNTCP (D(d)) proposing models are based on the relationship between the NTCP0/TNTCP and total dose (D = n×d; where d = dose per fraction, and n = number of fractions). TNTCP(D) model will be correlated with LKB model (the normal CDF) that is an increasing function; and NTCP0(D) model with a decreasing function, which additionally will define clear limits of three possible regions for NTCP0: 0 and 100% deterministic, and a stochastic. These models are function D, which is widely used for characterizing radiation therapies.



中文翻译:

当前无并发症治愈(P +)和不复杂肿瘤控制概率(UTCP)概念以及晚期并发症的总正常组织并发症概率的新制剂模型建议。

这项研究提出了总正常组织并发症概率(TNTCP)和NTCP0的现象学模型。NTCP0是新的首字母缩写词,用于重新定义当前的无并发症治愈(P +)和不复杂的肿瘤控制概率(UTCP)概念,而TNTCP将重新制定当前的NTCP,涉及处于风险中的多个器官。当前的概率概念是用与不同随机过程和随机变量相关的肿瘤控制概率(TCP)和正常组织并发症概率(NTCP)的数学运算来表示的。NTCP0等于NTCP 0(正常组织非并发症发生率),计算为没有晚期并发症的人群中的患者总数与总人数之比。作为晚期并发症的累积分布函数(CDF),TNTCP = sum(NTCP i),其中NTCP i是第i晚期并发症的NTCP 。TNTCP也是一个新的缩写,是NTCP0的概率补码,则NTCP0 = 100%-TNTCP。NTCP0 / TNTCP(D(d))提议模型基于NTCP0 / TNTCP与总剂量之间的关系(D  =  n × d;其中d =每小部分剂量,n=分数数)。TNTCP(D)模型将与LKB模型(正常CDF)相关,后者是一个递增函数;和具有递减函数的NTCP0(D)模型,该模型还将为NTCP0定义三个可能区域的明确限制:0和100%确定性,并且是随机的。这些模型是函数D,广泛用于表征放射治疗。

更新日期:2020-03-31
down
wechat
bug