Abstract

Objectives: To compare sizes and shapes of ablation zones resulting from hydrochloric acid infusion radiofrequency ablation (HRFA) and microwave ablation (MWA), using normal saline infusion radiofrequency ablation (NSRFA) as a control, at a variety of matched power settings and ablation durations, in an ex vivo bovine liver model.

Methods: A total of 90 ablation procedures were performed, using each of three modalities: NSRFA, HRFA, and MWA. For each modality, five ablation procedures were performed for each combination of power (80 W, 100 W, or 120 W) and duration (5, 10, 20, 30, 45, or 60 min). The size of ablation zones were compared using ANOVA, the Kruskal-Wallis test, or generalized linear regression.

Results: For ablation durations up to 30 min, mean transverse diameter (TD) after HRFA and MWA did not differ significantly (β = 0.13, p = .20). For ablation durations greater than 30 min, mean TD was significantly larger after HRFA than after MWA (β = 1.657, p < .001). The largest TD (9.46 cm) resulted from HRFA performed with 100 W power for 60 min.

Conclusions: Compared to MWA, monopolar HRFA with power settings of 80 W–120 W and durations of less than 30 min showed no significant difference. When duration of more than 30 min, HRFA created larger ablation zones than MWA.

摘要

目的：比较生理盐水注入射频消融（NSRFA）作为对照，在各种匹配的功率设置和消融持续时间下，比较盐酸输注射频消融（HRFA）和微波消融（MWA）产生的消融区域的大小和形状，在离体牛肝模型中。

方法：使用NSRFA，HRFA和MWA这三种方式中的每一种，共执行了90次消融手术。对于每种方式，针对功率（80 W，100 W或120 W）和持续时间（5、10、20、30、45或60分钟）的每种组合执行五次消融程序。使用ANOVA，Kruskal-Wallis检验或广义线性回归比较消融区的大小。

结果：对于长达30分钟的消融持续时间，HRFA和MWA后的平均横向直径（TD）差异不显着（β  = 0.13，p = .20）。对于大于30分钟的消融时间，HRFA后的平均TD明显大于MWA后的平均TD（β  = 1.657，p <.001）。HRFA产生的最大TD（9.46厘米）以100 W功率进行60分钟。

结论：与MWA相比，功率设置为80 W–120 W且持续时间少于30分钟的单极HRFA没有显着差异。当持续时间超过30分钟时，HRFA会创建比MWA更大的消融区。