Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. The objective was to assess relationships between OSA severity and biomarker levels. Patients with suspected OSA referred for a polysomnogram (PSG) provided fasting blood sample. Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and superoxide dismutase (SOD) were measured. The relationship between OSA and OS was assessed both before and after controlling for confounders (age, sex, smoking history, history of cardiovascular disease, ethnicity, diabetes, statin usage, body mass index (BMI)). 402 patients were studied (68% male, mean age ± SD = 50.8 ± 11.8 years, apnea-hypopnea index (AHI) = 22.2 ± 21.6 events/hour, BMI = 31.62 ± 6.49 kg/m²⁾. In a multivariable regression, the AHI significantly predicted 8-isoprostane levels (p = 0.0008) together with age and statin usage; AHI was not a predictor of 8-OHdG or SOD. Female sex (p < 0.0001) and no previous history of cardiovascular disease (p = 0.002) were associated with increased antioxidant capacity. Circulating 8-isoprostane levels may be a promising biomarker of the severity of oxidative stress in OSA patients. Prospective studies are needed to determine whether this biomarker is associated with long-term cardiometabolic complications in OSA.

中文翻译：

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阻塞性睡眠呼吸暂停和氧化应激的循环生物标志物：跨部门研究。

氧化应激（OS）驱动心脏代谢疾病。间歇性缺氧持续增加氧化应激指标。阻塞性睡眠呼吸暂停（OSA）患者经历间歇性缺氧并增加了心血管疾病的发生率，但是，尚不清楚OSA对OS标记物的影响。目的是评估OSA严重程度与生物标志物水平之间的关系。怀疑有OSA的患者通过多导睡眠图（PSG）进行了空腹血液采样。测量血浆中的8-异前列腺素，8-羟基脱氧鸟苷（8-OHdG）和超氧化物歧化酶（SOD）的水平。在控制混杂因素之前（包括年龄，性别，吸烟史，心血管疾病史，种族，糖尿病，他汀类药物使用，体重指数（BMI）），评估了OSA与OS之间的关系。研究了402例患者（68％的男性，^2）。在多变量回归中，AHI显着预测了8-异前列腺素水平（p = 0.0008）以及年龄和他汀类药物的使用。AHI不是8-OHdG或SOD的预测因子。女性（p <0.0001）和既往无心血管疾病史（p = 0.002）与抗氧化能力增强相关。循环中的8-异前列腺素水平可能是OSA患者氧化应激严重程度的有前途的生物标志物。需要进行前瞻性研究来确定这种生物标志物是否与OSA的长期心脏代谢并发症有关。