Even though Salvia genus is one of the most known and studied taxa of Lamiaceae family, the knowledge regarding the chemical composition and health-related benefits of some locally used Salvia species (mostly endemic) is still scarce. In this regard, the present work aims to evaluate the chemical profile and potential bioactivities of 70% (v/v) ethanolic extracts obtained from the less-studied S. transsylvanica and S. glutinosa in comparison with S. officinalis. HPLC-PDA analysis revealed the presence of rutin and catechin as the main compounds in the extracts of the three studied species (using the employed HPLC method), whereas the presence of naringenin was highlighted only in S. glutinosa extract. Chlorogenic acid, rutin and quercetin were identified and quantified for the first time in S. transsylvanica extracts. The in vitro antioxidant capacity of each extract was tested through complementary methods (phosphomolybdenum assay, DPPH, ABTS, CUPRAC and FRAP assays), and correlated with the presence of phenolics (especially flavonoids) in high amounts. The neuroprotective and antidiabetic abilities of S. officinalis (the most active as AChE, BChE and α-glucosidase inhibitor), S. glutinosa (the most active as α-amylase inhibitor) and S. transsylvanica were also studied. For each extract it was determined the antimicrobial, antifungal and cytotoxic effects using in vitro assays. The obtained results confirm the potential of S. transsylvanica and S. glutinosa as promising sources of bioactive compounds and as a starting point for further analyses.

中文翻译：

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鼠尾草物种的化学成分和生物活性：鼠尾草，S.glutinosa L.和S.transsylvanica（Schur ex Griseb。＆Schenk）之间的比较。

尽管丹参属是唇形科的最著名和研究过的分类单元之一，但有关一些当地使用的丹参属种（主要是地方性）的化学成分和与健康相关的益处的知识仍然很少。在这方面，本工作旨在评估从药用研究较少的S. transsylvanica和S. glutinosa中获得的70％（v / v）乙醇提取物的化学特征和潜在的生物活性。HPLC-PDA分析显示，在三个研究物种的提取物中，芦丁和儿茶素是主要成分（使用所采用的HPLC方法），而柚皮素的存在仅在芥蓝提取物。首次在反式葡萄球菌提取物中鉴定和定量了绿原酸，芦丁和槲皮素。通过补充方法（磷钼法，DPPH，ABTS，CUPRAC和FRAP法）测试了每种提取物的体外抗氧化能力，并与大量酚类化合物（尤其是类黄酮）的存在相关。的神经保护和抗糖尿病能力鼠尾草（最活跃的作为乙酰胆碱酯酶，和BChE的α葡萄糖苷酶抑制剂），S.黄（最活跃的作为α淀粉酶抑制剂）和S. transsylvanica还进行了研究。对于每种提取物，使用体外测定确定了其抗微生物，抗真菌和细胞毒性作用。所获得的结果证实的电位S. transsylvanica和S.黄作为有希望的生物活性化合物的源和作为起点用于进一步分析。