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BippyPhos: A Highly Versatile Ligand for Pd‐Catalyzed C−N, C−O and C−C Couplings
Israel Journal of Chemistry ( IF 3.2 ) Pub Date : 2020-03-18 , DOI: 10.1002/ijch.201900170
Robert A. Singer 1
Affiliation  

Numerous ligands have been designed for the Buchwald‐Hartwig Amination (BHA). Among the ligands developed is BippyPhos. This ligand was originally designed to enable a coupling of primary amines with aryl halides. Further studies showed that the ligand has fairly broad utility for Pd‐catalyzed C−N, C−O and C−C couplings. This review describes the various Pd‐catalyzed applications involving BippyPhos as a supporting ligand. While BippyPhos may not often be the most optimal ligand for various Pd‐catalyzed couplings, it typically will provide adequate results as a starting point prior to screening for optimization.

中文翻译:

BippyPhos:一种高度通用的配体,用于Pd催化的CN,CO和CC偶联

已经为布赫瓦尔德-哈特维希胺化(BHA)设计了许多配体。在开发的配体中有BippyPhos。最初设计该配体是为了使伯胺与芳基卤化物偶合。进一步的研究表明,该配体对Pd催化的C-N,C-O和C-C偶联具有相当广泛的用途。这篇综述描述了以BippyPhos为配体的各种Pd催化应用。虽然BippyPhos可能不一定经常是各种Pd催化偶联的最佳配体,但通常可以在筛选优化之前作为起点提供足够的结果。
更新日期:2020-03-18
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