A perspective of our work on the development of practical metal‐mediated carbon‐carbon and carbon‐heteroatom bond forming processes within a modern drug portfolio is presented. The case studies selected from our laboratories highlight the synthetic challenges and opportunities presented by pharmaceutically relevant scaffolds. In many cases, the target structures challenged available synthetic methods and inspired the invention of enabling technology to accelerate drug development. Additionally, considerations for running metal‐mediated processes on large scale are discussed.

中文翻译：

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通过金属介导的键形成促进药物开发

介绍了我们在现代药物组合中开发实用的金属介导的碳-碳和碳-杂原子键形成工艺的工作前景。从我们实验室中选择的案例研究突出了药物相关支架所带来的综合挑战和机遇。在许多情况下，目标结构挑战了可用的合成方法，并激发了使技术加速药物开发的发明。此外，还讨论了大规模运行金属介导过程的注意事项。