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An Expedient Route to 9‐Arylmethylanthracene Derivatives via Tandem Ni‐Catalyzed Alkene Dicarbofunctionalization and Acid‐Promoted Cyclization‐Aromatization
Israel Journal of Chemistry ( IF 3.2 ) Pub Date : 2020-02-14 , DOI: 10.1002/ijch.201900158
Doleshwar Niroula 1 , Rishi R. Sapkota 1 , Roshan K. Dhungana 1 , Bijay Shrestha 1, 2 , Ramesh Giri 1
Affiliation  

We report a nickel‐catalyzed one pot synthesis of 9‐arylmethylanthracene motifs, which find applications in medicinal and material chemistry. In this synthesis, we apply three component alkene dicarbofunctionalization of 2‐vinylaldimines with aryl iodides and arylzinc reagent to generate a 1,1,2‐diarylethyl scaffold, which then undergoes an acid‐promoted cyclization followed by aromatization to furnish 9‐arylmethylanthracene cores. With the new method, a number of differently‐substituted 9‐arylmethylanthracene derivatives can be synthesized in good yields.

中文翻译:

通过串联镍催化的烯烃双碳官能化和酸促进的环化-芳构化制取9芳基甲基蒽衍生物的简便方法

我们报道了镍催化的一锅合成9-芳基甲基蒽基序,发现其在药物和材料化学中的应用。在该合成中,我们将2-乙烯基醛亚胺与芳基碘化物和芳基锌试剂的三组分烯烃双碳官能化生成1,1,2-二芳基乙基支架,然后对其进行酸促进的环化,然后进行芳构化以提供9-芳基甲基蒽核心。使用新方法,可以高收率合成许多不同取代的9-芳基甲基蒽衍生物。
更新日期:2020-02-14
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