COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

由SARS-CoV-2感染引起的COVID-19疾病与一系列生理病理学机制有关，这些机制动员了多种生物分子，主要是免疫分子。在最严重的情况下，主要通过靶向肺组织的主要促炎细胞因子（例如IL-1，IL-6，IL-12，IFN-γ和TNF-α）的过量生产，可使预后明显恶化。这项研究回顾了需要入院重症监护病房的COVID-19患者不同细胞因子表达变化的公开数据。细胞因子对这种疾病的影响及其对预后的影响的数据将支持设计更有效的COVID-19管理方法。