Abstract

Supercritical fluid encapsulation of doxycycline into aliphatic polyesters was used to fabricate bioresorbable antibacterial polylactoglycolide scaffolds. The distributions of doxycycline concentration on the surface and in the bulk of polymer structures were analyzed using high (≈1 μm) spatial resolution Raman spectroscopy. The release kinetics of doxycycline from these scaffolds into saline solution was studied. It is shown that, with the exception of the first 3 h, when about 15% of its total amount goes into the solution, the release of doxycycline occurs almost linearly. During the first day, the total yield of the antibiotic was about 22%. In 15 days (maximum observation time), the total amount of doxycycline released from polylactoglycolide scaffolds was about 70%. Thus, bioresorbable polymer scaffolds fabricated with supercritical carbon dioxide can be used for local sustained release of antibiotics, as well as for biologically active scaffolds for tissue engineering.

中文翻译：

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超临界二氧化碳包裹聚乳酸乙交酯支架中强力霉素的释放动力学

摘要

将多西环素超临界流体封装到脂肪族聚酯中用于制造可生物吸收的抗菌性聚乳酸聚乙二醇内酯支架。使用高（≈1μm）空间分辨率拉曼光谱分析了强力霉素在聚合物表面和主体结构中的浓度分布。研究了强力霉素从这些支架向盐溶液中的释放动力学。结果表明，除了前3小时，当溶液总量的约15％进入溶液时，强力霉素的释放几乎呈线性发生。在第一天，抗生素的总产率为约22％。在15天（最长观察时间）中，从聚乳酸乙交酯支架释放的强力霉素总量约为70％。从而，